Description

O,O'-Bis(3-Aminopropyl)Polyethylene Glycol 1'500 is a bifunctional amine-terminated polyethylene glycol derivative, serving as a versatile hydrophilic spacer and linker in advanced material synthesis. Its primary value lies in its ability to introduce reactive amine groups and PEG chains, enhancing solubility, reducing immunogenicity, and enabling controlled conjugation. This product is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and specialty polymer industries who require precise, high-purity building blocks for drug delivery systems, hydrogels, and surface modifications.

Application

• Pharmaceutical Conjugation: As a key linker for PEGylating peptides, proteins, and oligonucleotides to improve pharmacokinetic profiles and stability.
• Biomaterial Fabrication: A cross-linking agent and hydrophilic modifier in the synthesis of hydrogels for tissue engineering and controlled release matrices.
• Surface Functionalization: Used to create amine-reactive coatings on nanoparticles, diagnostic beads, and medical device surfaces to enable further biomolecule attachment.
• Polymer Chemistry: A macromonomer or chain extender in the production of polyurethanes, polyamides, and other specialty copolymers requiring hydrophilic segments.
• Diagnostic Reagents: Employed in the development of fluorescent probes, assay components, and biosensor interfaces where water solubility and low non-specific binding are critical.
• Gene Delivery Systems: A component in the design of non-viral vectors, such as lipid nanoparticles (LNPs) and polyplexes, to enhance biocompatibility and transfection efficiency.

Basic Information

Product Name	O,O'-Bis(3-Aminopropyl)Polyethylene Glycol 1'500
CAS No.	34901-14-9
Molecular Formula	CnH2n+2O(n/2)+2N2 (n~34, approximate for PEG 1500)
Molecular Weight	~1,500 g/mol (Average Mn)
Synonyms	α,ω-Bis(3-aminopropyl)polyethylene glycol 1500; PEG1500 diamine; Poly(ethylene glycol) bis(3-aminopropyl) terminated; Jeffamine® EDR-148 (similar class); Bis(3-aminopropyl) PEG; 3,3'-(Oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine); Amino-PEG-amine; Diamino-PEG1500; Polyoxyethylene bis(3-aminopropyl) ether
EINECS	Contact for details

Quality Control

Our O,O'-Bis(3-Aminopropyl)Polyethylene Glycol 1'500 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity. Key parameters such as amine value, water content, and polydispersity are controlled. Certificates of Analysis (COA) detailing specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccant or storing under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Average Molecular Weight (Mn)	1,400 - 1,600 g/mol
Amine Value	0.60 - 0.75 meq/g
Water Content (KF)	≤ 1.0 %
Polydispersity Index (PDI)	≤ 1.10
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.