Description

Nystatin A1 Trihydrate CAS NO 34786-70-4 is a polyene macrolide antifungal antibiotic, specifically a trihydrate form of the Nystatin A1 component. This compound is valued for its potent fungicidal and fungistatic activity against a broad spectrum of Candida species and other yeasts. It is a critical active pharmaceutical ingredient (API) and intermediate for manufacturers in the pharmaceutical, veterinary medicine, and research sectors requiring high-purity antifungal agents.

Application

• Pharmaceutical API: Primary active ingredient in topical antifungal creams, ointments, powders, and oral suspensions for the treatment of cutaneous, oral, and intestinal candidiasis.
• Veterinary Medicine: Used in formulations to treat fungal infections in livestock, poultry, and companion animals.
• Biomedical Research: Essential reference standard and tool for studying antifungal mechanisms of action, resistance development, and for in vitro susceptibility testing.
• Cosmecutical Preservative: Incorporated into specific personal care products to prevent yeast and mold contamination.
• Intermediate Synthesis: Serves as a key starting material or intermediate for the synthesis of novel antifungal derivatives and prodrugs.

Basic Information

Product Name	Nystatin A1 Trihydrate
CAS No.	34786-70-4
Molecular Formula	C47H75NO17 • 3H2O
Molecular Weight	926.09 g/mol (Anhydrous basis: 872.03 g/mol)
Synonyms	Nystatin A1; Nystatin A1 Trihydrate; Nystatin A1 3H2O; Fungicidin; Mycostatin (component); Antibiotic A 5283; Nystatin Component A1; Polyene Antibiotic A 5283; NSC 245194
EINECS	Contact for details

Quality Control

Our Nystatin A1 Trihydrate is manufactured and tested under strict quality management systems. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, purity, potency, and related substances. We ensure compliance with relevant pharmacopeial guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	5.0% - 7.0% (Theoretical for Trihydrate: ~5.8%)
Specific Rotation	Contact for details
pH (in suspension)	6.0 - 8.0
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.