Description

H2N-PEG14-OH is a high-purity, amine-terminated polyethylene glycol (PEG) derivative with a molecular weight of approximately 700 g/mol. This bifunctional linker is essential for creating stable, hydrophilic spacers in bioconjugation and drug delivery systems, improving solubility and reducing immunogenicity. It is a critical building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science.

Application

• Bioconjugation and PEGylation: Used to attach therapeutic proteins, peptides, or small molecule drugs to PEG chains, enhancing their pharmacokinetic properties.
• Crosslinking Agent: Serves as a heterobifunctional crosslinker for coupling amine-reactive molecules (via the terminal amine) to hydroxyl-reactive molecules.
• Drug Delivery Systems: A key component in the synthesis of polymer-drug conjugates, dendrimers, and micellar nanoparticles for targeted delivery.
• Surface Modification: Employed to create non-fouling, hydrophilic surfaces on biomaterials and diagnostic devices.
• Proteomics Research: Useful for labeling peptides or modifying surfaces of biosensors and microarrays.
• Hydrogel Formation: Acts as a building block in the creation of biocompatible hydrogels for tissue engineering and controlled release applications.

Basic Information

Product Name	H2N-PEG14-OH
CAS No.	34214-89-6
Molecular Formula	C28H59NO15
Molecular Weight	~ 697.8 g/mol
Synonyms	14-Amino-3,6,9,12-tetraoxatetradecan-1-ol; Amino-PEG14-alcohol; α-Amino-ω-hydroxy-tetraethylene glycol; 2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol; Amino-PEG4-OH (based on 4 ethylene oxide units in the core chain); O-(2-Aminoethyl)-O′-(2-hydroxyethyl)tetraethylene glycol; Amine-PEG-tetrol (informal); H2N-PEG4-OH
EINECS	Contact for details

Quality Control

Our H2N-PEG14-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for amine content, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Amine Value (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.