Description

Celastrol is a bioactive quinone methide triterpenoid isolated from the root extracts of the *Tripterygium wilfordii* (Thunder God Vine) plant. This compound is of significant interest for its potent biological activity, serving as a valuable reference standard and a key starting material for research into novel therapeutic pathways. It is primarily sought by researchers and developers in the pharmaceutical, biotechnology, and nutraceutical sectors. Celastrol CAS NO 34157-83-0 is essential for studies focused on inflammation, metabolic disorders, and oncology.

Application

• Pharmaceutical Research & Development: Used as a high-purity reference standard for analytical method development, validation, and quality control in drug discovery pipelines.
• Preclinical Studies: Employed in in vitro and in vivo models to investigate its mechanisms of action, particularly related to anti-inflammatory, anti-cancer, and neuroprotective effects.
• Natural Product & Nutraceutical Analysis: Serves as a critical marker compound for the standardization, authentication, and potency assessment of botanical extracts containing *Tripterygium wilfordii*.
• Biochemical Pathway Research: A vital tool for probing cellular signaling pathways, including those involving heat shock proteins (HSPs), NF-κB, and various kinases.
• Academic Research: Utilized in universities and research institutes for fundamental studies in pharmacology, cell biology, and medicinal chemistry.

Basic Information

Product Name	Celastrol
CAS No.	34157-83-0
Molecular Formula	C29H38O4
Molecular Weight	450.61 g/mol
Synonyms	Tripterine; Celastrol (Tripterine); 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid; (2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; NSC 199964; PR 977; TT1; Qian Ceng Ta
EINECS	Contact for details

Quality Control

Our Celastrol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, MS, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.