Description

Penicillamine is a key pharmaceutical intermediate and a potent chelating agent derived from the degradation of penicillin. Its primary commercial value lies in its ability to bind to and facilitate the excretion of heavy metals, making it a critical component in therapeutic and industrial detoxification processes. This compound is essential for manufacturers in the pharmaceutical, research, and chemical synthesis sectors, particularly for producing metal-chelating drugs and as a building block for more complex molecules.

Application

• Pharmaceutical Active Ingredient (API): Used in the formulation of drugs for the treatment of Wilson's disease, rheumatoid arthritis, and cystinuria.
• Heavy Metal Chelation Therapy: Serves as the active agent in medications designed to remove excess copper, lead, mercury, and other toxic metals from the body.
• Biochemical Research: Employed in laboratory studies as a thiol reagent for reducing disulfide bonds in proteins and enzymes.
• Chemical Synthesis Intermediate: Utilized as a chiral building block and precursor in the synthesis of more complex organic compounds and specialty chemicals.
• Veterinary Medicine: Applied in formulations for treating copper accumulation disorders in animals.
• Industrial Process Aid: Acts as a stabilizer or chelating agent in specific niche chemical manufacturing processes.

Basic Information

Product Name	Penicillamine
CAS No.	34138-28-8
Molecular Formula	C5H11NO2S
Molecular Weight	149.21 g/mol
Synonyms	D-Penicillamine; (2S)-2-Amino-3-methyl-3-sulfanylbutanoic acid; 3-Mercapto-D-valine; β,β-Dimethylcysteine; D-3-Mercaptovaline; Cuprimine; Depen; Distamine; Metalcaptase; Mercaptyl; Pendramine
EINECS	251-861-5

Quality Control

Our Penicillamine is manufactured and tested under a strict quality management system. We offer material compliant with major pharmacopoeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing for identity, purity, and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	-61.0° to -65.0° (c=1, 1N HCl)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.