Description

p-Fluorophenyl 4-(p-Fluorophenyl)-4-Hydroxy-1-Methyl-3-Piperidyl Ketone Hydrochloride is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery and development. Its complex piperidine-based structure makes it a valuable building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. This compound is primarily sought after by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for neurological and psychiatric applications.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the efficient, large-scale production of target compounds.
• Reference Standard: Used as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Biochemical Tool Compound: Utilized in pharmacological assays to study receptor interactions and biological pathways.

Basic Information

Product Name	p-Fluorophenyl 4-(p-Fluorophenyl)-4-Hydroxy-1-Methyl-3-Piperidyl Ketone Hydrochloride
CAS No.	34039-01-5
Molecular Formula	C19H19F2NO2·HCl
Molecular Weight	375.82 g/mol (Free base: 339.36 g/mol)
Synonyms	4-(4-Fluorophenyl)-1-methyl-4-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-ol hydrochloride; 1-Methyl-4-(4-fluorobenzoyl)-4-(4-fluorophenyl)-4-piperidinol hydrochloride; 4-(4-Fluorophenyl)-4-hydroxy-1-methyl-3-piperidyl 4-fluorophenyl ketone hydrochloride; 4-(p-Fluorobenzoyl)-4-(p-fluorophenyl)-1-methyl-4-piperidinol hydrochloride; 4-Hydroxy-1-methyl-4-(4-fluorophenyl)-3-[4-(4-fluorophenyl)-4-oxobutyl]piperidine hydrochloride; CAS 34039-01-5
EINECS	Contact for details

Quality Control

Our p-Fluorophenyl 4-(p-Fluorophenyl)-4-Hydroxy-1-Methyl-3-Piperidyl Ketone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.