Description

6-Fluoro-2-Chloropyrazine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique halogenated pyrazine structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and chlorine substituents into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated and chlorinated drug candidates, particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the pyrazine core provides specific biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Nucleophilic Aromatic Substitution: The chlorine and fluorine atoms are amenable to displacement with various nucleophiles, enabling rapid diversification of the pyrazine ring.
• Ligand and Catalyst Development: Used to synthesize novel nitrogen-containing ligands for metal complexes in catalytic applications.

Basic Information

Product Name	6-Fluoro-2-Chloropyrazine
CAS No.	33873-10-8
Molecular Formula	C4H2ClFN2
Molecular Weight	132.52 g/mol
Synonyms	2-Chloro-6-fluoropyrazine; 6-Fluoro-2-chloropyrazine; 2-Chloro-6-fluoro-1,4-diazine; Fluorochloropyrazine; Pyrazine, 2-chloro-6-fluoro-; 33873-10-8 (CAS); FCMP
EINECS	Contact for details

Quality Control

Our 6-Fluoro-2-Chloropyrazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP or ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.