Description

(3Ar)-3Aβ,4,5,5A,6,7,8,9,9A,9Bα-Decahydro-4β,9Aβ-Dihydroxy-5Aα-Methyl-3,9-Bis(Methylene)Naphtho[1,2-B]Furan-2(3H)-One is a complex sesquiterpene lactone derivative with a unique fused furanone structure. This compound is valued as a key synthetic intermediate and a scaffold for advanced chemical synthesis due to its intricate stereochemistry and functional groups. It is primarily sought by pharmaceutical research and fine chemical synthesis sectors for developing novel active ingredients and exploring new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis due to its complex polycyclic framework.
• Natural Product Synthesis: Acts as a key intermediate in the total synthesis of complex natural products and their analogs.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring high-purity, stereochemically defined intermediates.
• Biochemical Research: Potential use as a probe or inhibitor in enzymatic studies, leveraging its reactive lactone moiety.

Basic Information

Item	Detail
Product Name	(3Ar)-3Aβ,4,5,5A,6,7,8,9,9A,9Bα-Decahydro-4β,9Aβ-Dihydroxy-5Aα-Methyl-3,9-Bis(Methylene)Naphtho[1,2-B]Furan-2(3H)-One
CAS No.	33530-73-3
Molecular Formula	C17H22O4
Molecular Weight	290.35 g/mol
Synonyms	4,9-Dihydroxy-5α-methyl-3,9-bis(methylene)decahydronaphtho[1,2-b]furan-2(3H)-one; 3,9-Bis(methylene)-4,9-dihydroxy-5α-methyl-decahydronaphtho[1,2-b]furan-2(3H)-one; Parthenolide analog; Parthenolide derivative; Sesquiterpene lactone intermediate; Naphthofuranone derivative
EINECS	Contact for details

Quality Control

Our production of (3Ar)-3Aβ,4,5,5A,6,7,8,9,9A,9Bα-Decahydro-4β,9Aβ-Dihydroxy-5Aα-Methyl-3,9-Bis(Methylene)Naphtho[1,2-B]Furan-2(3H)-One adheres to stringent quality protocols suitable for research and development applications. All batches are characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and related substances are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized; prolonged exposure to air should be avoided. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% de
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.