Description

Capreomycin Ib CAS NO 33490-33-4 is a key cyclic peptide antibiotic belonging to the capreomycin family, primarily used as a second-line therapeutic agent. Its significance lies in its targeted activity against Mycobacterium tuberculosis, particularly in multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) cases. This makes it a critical component in the global pharmaceutical supply chain for anti-tuberculosis treatments. Pharmaceutical manufacturers and research institutions developing specialized antibiotic formulations are the primary users of this high-purity compound.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of second-line injectable anti-tuberculosis drugs.
• Drug Combination Therapies: Used in combination with other antibiotics for treating multidrug-resistant tuberculosis (MDR-TB).
• Pharmaceutical Research & Development: Serves as a reference standard and starting material in the R&D of new anti-mycobacterial agents.
• Clinical Trial Material: Supplied as a high-purity compound for clinical studies evaluating new TB treatment regimens.
• Microbiological Studies: Used in in vitro studies to determine bacterial susceptibility and resistance mechanisms.

Basic Information

Product Name	Capreomycin Ib
CAS No.	33490-33-4
Molecular Formula	C25H44N14O8
Molecular Weight	668.71 g/mol
Synonyms	Capreomycin 1B; Capreomycin I; Capreomycin IA; Capastat component Ib; (S)-4,6-Diamino-N-((1R,2S,3S,4R,5S)-5-amino-2-((S)-2-amino-3-guanidinopropanamido)-1,3,4-trihydroxycyclohexyl)-6-(hydroxymethyl)-3-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; Antibiotic A-399; Antibiotic FR-399; NSC-110364
EINECS	Contact for details

Quality Control

Our Capreomycin Ib is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing compliance with agreed specifications. Our commitment to cGMP standards ensures reliability for critical therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Microbial Limits	Meets Ph. Eur. requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.