Description

2-Chloro-6-Methoxypyrazine is a versatile heterocyclic building block and key synthetic intermediate prized for its unique chemical reactivity. Its value lies in enabling the efficient construction of complex molecular architectures, particularly in the development of high-value fine chemicals and active pharmaceutical ingredients. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific pyrazine motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various drug candidates, including potential kinase inhibitors, antiviral agents, and other bioactive molecules containing the pyrazine scaffold.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the chloromethoxypyrazine structure imparts specific biological activity.
• Flavor & Fragrance Chemistry: Serves as a key intermediate for creating synthetic aroma chemicals, as methoxypyrazines are known to contribute green, earthy, or bell pepper-like notes in complex fragrance and flavor formulations.
• Material Science Research: Employed as a building block for constructing novel organic ligands, coordination polymers, or functional materials with tailored electronic or photophysical properties.
• Chemical Research & Development: A valuable reagent for method development in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution, facilitating the exploration of new synthetic pathways.

Basic Information

Product Name	2-Chloro-6-Methoxypyrazine
CAS No.	33332-30-8
Molecular Formula	C5H5ClN2O
Molecular Weight	144.56 g/mol
Synonyms	2-Chloro-6-methoxypyrazine; 6-Chloro-2-methoxypyrazine; 2-Methoxy-6-chloropyrazine; 2-Chloro-6-methoxy-1,4-diazine; NSC 403116; Pyrazine, 2-chloro-6-methoxy-; 6-Methoxy-2-chloropyrazine
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Methoxypyrazine is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP and ISO standards for reliable sourcing in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Melting Point	Contact for details
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.