Description

1-(4-(3-Chloro-4-(1-Methylethyl)Phenyl)-1-Oxobutyl)-4-Methylpiperazine Hydrochloride is a high-purity, non-racemic organic compound that serves as a critical chiral intermediate in advanced pharmaceutical synthesis. Its value lies in providing a structurally defined, enantiomerically pure building block essential for developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements. This product is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Process Development & Scale-Up: Serves as a validated starting material or intermediate for pilot plant and commercial manufacturing under cGMP conditions.
• Asymmetric Synthesis: Utilized in reactions requiring high enantioselectivity to introduce the piperazine moiety with defined stereochemistry.
• Reference Standard: Acts as an analytical standard for quality control and method validation in API production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-(4-(3-Chloro-4-(1-Methylethyl)Phenyl)-1-Oxobutyl)-4-Methylpiperazine Hydrochloride
CAS No.	32808-60-9
Molecular Formula	C18H27ClN2O•HCl
Molecular Weight	359.34 g/mol
Synonyms	4-Methyl-1-[4-[3-chloro-4-(1-methylethyl)phenyl]-4-oxobutyl]piperazine Hydrochloride; 1-(4-(3-Chloro-4-isopropylphenyl)-4-oxobutyl)-4-methylpiperazine Hydrochloride; (R/S)-1-[4-[3-Chloro-4-(1-methylethyl)phenyl]-4-oxobutyl]-4-methylpiperazine Hydrochloride; 4-Methyl-1-(4-oxo-4-(3-chloro-4-isopropylphenyl)butyl)piperazine HCl; UNII-9Q2F8M6P6I; 9Q2F8M6P6I; Chiral Piperazine Derivative Hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-(3-Chloro-4-(1-Methylethyl)Phenyl)-1-Oxobutyl)-4-Methylpiperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.