Description

Ho-Peg-Nh2 CAS NO 32130-27-1 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a hydroxyl group at one terminus and a primary amine at the other. This unique structure makes it a versatile linker and spacer molecule for bioconjugation, enabling the coupling of biomolecules, drugs, or surfaces with different reactive groups. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, water-soluble linkers to modify peptides, proteins, and other active compounds, thereby improving solubility, stability, and pharmacokinetic properties.

Application

• Bioconjugation and PEGylation: Used as a heterobifunctional crosslinker to attach drugs, dyes, or targeting ligands to proteins, antibodies, and peptides, enhancing their therapeutic profile.
• Drug Delivery Systems: Serves as a key component in constructing prodrugs and nanoparticle-based delivery platforms to improve drug solubility and reduce immunogenicity.
• Surface Functionalization: Employed to modify biosensor surfaces, microarray slides, and medical device coatings to introduce amine-reactive sites for further biomolecule immobilization.
• Polymer Chemistry: Acts as a macromonomer or initiator for synthesizing block copolymers and functional hydrogels with tailored properties.
• Diagnostic Reagents: Utilized in the development of diagnostic assays and imaging agents by linking detection molecules (e.g., fluorophores) to antibodies or other probes.

Basic Information

Product Name	Ho-Peg-Nh2 CAS NO 32130-27-1
CAS No.	32130-27-1
Molecular Formula	CnH2n+2On+1NH2 (n varies by PEG chain length)
Molecular Weight	Variable (dependent on PEG chain length, e.g., 1kDa, 2kDa, 5kDa, 10kDa, 20kDa)
Synonyms	HO-PEG-NH2; α-Hydroxy-ω-amino Polyethylene Glycol; Amino-PEG-alcohol; Heterobifunctional PEG Amine; Poly(ethylene glycol) methyl ether amine (with terminal OH); PEG Diol Monoamine; Amino-PEG-OH; 2-Aminoethyl polyethylene glycol
EINECS	Contact for details

Quality Control

Our Ho-Peg-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and HPLC, to confirm structure, purity, and functional group integrity. Certificates of Analysis (COA) detailing molecular weight distribution, amine value, and hydroxyl value are available upon request. We support cGMP production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive). Under inert atmosphere (argon or nitrogen) is recommended for optimal shelf life.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95%
Molecular Weight (Average)	As per ordered grade (e.g., 1000, 2000, 5000 Da)
Polydispersity Index (PDI)	≤ 1.05
Amine Value	As per theoretical calculation (±10%)
Water Content (KF)	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.