Description

Sulindac Sulfide is a potent and specific active metabolite of the non-steroidal anti-inflammatory drug (NSAID) Sulindac. This compound is of significant interest in pharmaceutical research and development due to its distinct biological profile and role as a key intermediate. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in anti-inflammatory drug discovery, metabolic studies, and the synthesis of advanced pharmaceutical ingredients.

Application

• Pharmaceutical Intermediate: A critical metabolite and synthetic precursor in the production and study of the NSAID Sulindac and its analogs.
• Biochemical Research: Used as a reference standard and active compound in studies investigating cyclooxygenase (COX) inhibition, anti-inflammatory mechanisms, and cellular signaling pathways.
• Metabolite Standard: Essential for analytical method development and validation in pharmacokinetic and bioequivalence studies for Sulindac.
• Drug Discovery: Serves as a lead compound or chemical scaffold for the design and synthesis of novel anti-inflammatory agents with potentially improved efficacy or safety profiles.
• Quality Control: Employed as an impurity reference standard in the quality assurance and control of bulk Sulindac and its finished dosage forms.

Basic Information

Product Name	Sulindac Sulfide
CAS No.	32004-67-4
Molecular Formula	C20H17FO2S
Molecular Weight	340.41 g/mol
Synonyms	(Z)-5-Fluoro-2-methyl-1-[(4-methylsulfinyl)phenyl]methylene-1H-indene-3-acetic acid sulfide; (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid sulfide; Sulindac Sulphide; Sulindac Sulfide Metabolite; FGN-1; Z-5-Fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)indene-3-acetic acid sulfide
EINECS	Contact for details

Quality Control

Our Sulindac Sulfide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and impurity profiling, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.