Description

o-Methyl-O'-Succinylpolyethylene Glycol is a functionalized polyethylene glycol derivative, widely used as a versatile linker and solubilizing agent in advanced chemical synthesis. Its bifunctional structure, featuring a methyl ether and a reactive succinyl ester terminus, provides a critical tool for modifying biomolecules and polymers to enhance their properties. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and specialty polymer industries, where precise conjugation and controlled release applications are paramount.

Application

• Pharmaceutical Conjugation: A key intermediate for PEGylating peptides, proteins, and small molecule drugs to improve solubility, stability, and pharmacokinetic profiles.
• Bioconjugation Linker: Used to create stable amide bonds between active molecules and carriers, nanoparticles, or surfaces in diagnostic and therapeutic agent development.
• Polymer Modification: Serves as a functional monomer or chain extender to introduce hydrophilic PEG segments and reactive sites into co-polymers and hydrogels.
• Prodrug Synthesis: Facilitates the design of prodrugs by providing a cleavable ester linkage for controlled drug release.
• Surface Functionalization: Employed to modify material surfaces (e.g., nanoparticles, medical devices) with biocompatible, non-fouling PEG layers.
• Cross-linking Agent: Acts as a water-soluble cross-linker in the formation of biodegradable networks for tissue engineering and drug delivery matrices.

Basic Information

Product Name	o-Methyl-O'-Succinylpolyethylene Glycol
CAS No.	31961-02-1
Molecular Formula	CnH2n+2Om (Variable, based on PEG chain length)
Molecular Weight	Variable (Typically 350 - 5000 g/mol). Contact for details.
Synonyms	mPEG-Succinate; α-Methyl-ω-succinylpoly(ethylene glycol); Methoxy PEG Succinate; Poly(ethylene glycol) methyl ether succinate; Succinic acid mono(methoxypolyethylene glycol) ester; PEG Methyl Ether Succinate; mPEG-SA; SC-mPEG
EINECS	Contact for details.

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. Quality is verified through analytical methods including HPLC for purity and assay, NMR for structural confirmation, and GPC/SEC for molecular weight distribution. Certificates of Analysis (COA) detailing specifications for the requested molecular weight grade are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere or with desiccant to prevent moisture uptake. For long-term storage, temperatures of 2-8°C are advised.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Molecular Weight (GPC/SEC)	As per ordered grade (e.g., 350, 550, 750, 2000, 5000 Da)
Polydispersity Index (PDI)	≤ 1.05 - 1.20 (Grade dependent)
Succinate Substitution	≥ 90%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.