Description

Cyclobutanecarboxylic Acid, 2-(Chloroformyl)-, cis- (8Ci) is a high-purity, cis-configured carboxylic acid derivative featuring a reactive acid chloride functional group. This compound is a critical chiral building block in advanced organic synthesis, enabling the precise construction of complex molecular architectures. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel therapeutic agents, particularly in the development of central nervous system (CNS) and anti-inflammatory drugs.
• Peptide Mimetics & Conjugation: Used in the preparation of constrained, non-natural amino acids and for the site-specific modification of peptides and proteins.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced, stereospecific herbicides and fungicides with improved efficacy.
• Ligand & Catalyst Development: Employed in the creation of chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Research: Acts as a monomer or cross-linking agent in the research of specialized polymers with unique thermal or mechanical properties.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic chemistry and for scaling up synthetic routes in process development.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 2-(Chloroformyl)-, cis- (8Ci)
CAS No.	31838-29-6
Molecular Formula	C6H7ClO3
Molecular Weight	162.57 g/mol
Synonyms	cis-2-(Chlorocarbonyl)cyclobutanecarboxylic Acid; (1s,2s)-2-(Chloroformyl)cyclobutanecarboxylic Acid; (1R,2R)-rel-2-(Chlorocarbonyl)cyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 2-(chlorocarbonyl)-, (1R,2R)-rel-; 2-Carboxycyclobutanecarbonyl chloride, cis-; cis-Cyclobutane-1,2-dicarboxylic acid chloride (mono-); cis-1,2-Cyclobutanedicarboxylic acid monochloride
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 2-(Chloroformyl)-, cis- (8Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized using advanced analytical techniques including NMR, HPLC, and chiral analysis to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with strong bases and nucleophiles; it must be kept under an inert atmosphere (e.g., nitrogen or argon) and isolated from incompatible substances.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% cis-isomer
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.