Description

Estradiol-3-Dansylate is a dansyl chloride derivative of the primary female sex hormone, estradiol, designed for advanced analytical and research applications. This compound is critically important as a high-sensitivity fluorescent labeling reagent, enabling the detection and quantification of estradiol and related steroids in complex biological matrices. It is primarily needed by pharmaceutical R&D laboratories, clinical research organizations, and analytical service providers for method development, bioanalytical studies, and quality control in hormone analysis.

Application

• Fluorescent Derivatization Agent: Used as a pre-column or post-column derivatization reagent in High-Performance Liquid Chromatography (HPLC) with fluorescence detection for the ultra-sensitive analysis of estradiol.
• Biomarker Research: Employed in the development of assays to study estrogen metabolism, endocrine-disrupting chemicals, and hormonal pathways in clinical and environmental samples.
• Pharmaceutical Analysis: Facilitates the trace-level quantification of estradiol in drug formulations, stability studies, and pharmacokinetic/pharmacodynamic (PK/PD) research.
• Diagnostic Kit Development: Serves as a key component in developing sensitive immunoassays or chemical sensors for hormonal status monitoring.
• Metabolite Profiling: Aids in the identification and measurement of estrogen metabolites in urine, serum, or tissue samples for metabolic disorder studies.
• Reference Standard: Can be utilized as a certified reference material (CRM) or an internal standard in mass spectrometry (LC-MS/MS) for accurate quantification.

Basic Information

Product Name	Estradiol-3-Dansylate
CAS No.	30808-48-1
Molecular Formula	C30H35NO4S
Molecular Weight	505.67 g/mol
Synonyms	Estradiol 3-Dansylate; 17β-Estradiol 3-Dansylate; Oestra-1,3,5(10)-triene-3,17β-diol 3-(5-dimethylaminonaphthalene-1-sulfonate); 3-Dansylestradiol; Dansyl Estradiol; E2-Dansyl; Estradiol 3-(5-Dimethylaminonaphthalene-1-sulfonate); 17β-Estradiol 3-(Dansyl)
EINECS	Contact for details

Quality Control

Our Estradiol-3-Dansylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and analytical applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.