Description

Withanolide D(P) is a high-purity, naturally occurring steroidal lactone (withanolide) isolated from plants of the Solanaceae family, such as *Withania somnifera* (Ashwagandha). This compound is valued for its significant role as a reference standard and active pharmaceutical ingredient (API) in advanced research and development. It is primarily sought by pharmaceutical, nutraceutical, and biotechnology companies engaged in metabolic, neurological, and anti-inflammatory research, as well as by analytical laboratories for quality control and method validation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and purity testing of herbal extracts and finished products in quality control laboratories.
• Bioactivity Research: Serves as a key investigational compound in preclinical studies targeting anti-inflammatory, neuroprotective, immunomodulatory, and anti-cancer pathways.
• Nutraceutical Standardization: Employed to standardize Ashwagandha and other adaptogenic herbal extracts, ensuring consistent potency and efficacy in dietary supplement formulations.
• Analytical Method Development: Essential for developing and validating analytical methods such as HPLC, LC-MS, and TLC in research and regulatory settings.
• Natural Product Chemistry: Used as a building block or intermediate in the semi-synthesis of novel withanolide derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Withanolide D(P)
CAS No.	30655-48-2
Molecular Formula	C28H38O6
Molecular Weight	470.60 g/mol
Synonyms	Withanolide D; Withaferin D; (22R)-5,6:22,26-Diepoxy-4,27-dihydroxy-1-oxoergosta-2,24-dienolide; (22R)-14α,15α-Epoxy-3β,27-dihydroxy-1-oxoergosta-2,24-dienolide; Withanolide D (from W. somnifera); NSC 369754
EINECS	Contact for details

Quality Control

Our Withanolide D(P) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all test results are provided to ensure compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.