Description

1-(4-Trifluoromethylphenyl)Piperazine is a versatile and high-value aromatic piperazine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the trifluoromethylphenyl moiety, which is instrumental in modulating the physicochemical and pharmacokinetic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) agents, including potential antidepressants, antipsychotics, and anxiolytics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in the design of novel ligands for catalysis and metal-organic frameworks (MOFs) due to its electron-withdrawing and steric properties.
• Material Science Research: Acts as a monomer or functionalizing agent in the synthesis of specialty polymers and advanced organic electronic materials.
• Chemical Biology & Proteomics: Utilized as a scaffold or linker in the design of molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, complex aromatic amines.

Basic Information

Product Name	1-(4-Trifluoromethylphenyl)Piperazine
CAS No.	30459-17-7
Molecular Formula	C11H13F3N2
Molecular Weight	230.23 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]piperazine; 4-(Piperazin-1-yl)benzotrifluoride; 4-(Trifluoromethyl)phenylpiperazine; 1-(4-Trifluorophenyl)piperazine; p-Trifluoromethylphenylpiperazine; 4-Trifluoromethyl-1-piperazinobenzene; TFMPP (common abbreviation); α-(4-Trifluoromethylphenyl)-piperazine
EINECS	Contact for details

Quality Control

Our 1-(4-Trifluoromethylphenyl)Piperazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.