Description

(14R)-5,6β,10,14,16-Pentahydroxygrayanotoxan-3-One is a high-purity diterpenoid compound belonging to the grayanotoxin family, known for its specific and potent biological activity. This compound is critical for advanced research and development in pharmacology and toxicology, serving as a precise reference standard and a key synthetic intermediate. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals for the development of novel therapeutic agents and analytical methods.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of grayanotoxin-related compounds in drug development and quality control.
• Pharmacological Research: Serves as a key active ingredient or probe in studies investigating sodium channel modulation, neurotoxicity, and cardiac effects.
• Toxicology Studies: Employed in the development of assays and diagnostic tools for the detection and study of grayanotoxin poisoning.
• Fine Chemical Synthesis: Acts as a sophisticated chiral building block or intermediate in the multi-step synthesis of complex natural product derivatives and potential drug candidates.
• Academic Research: Utilized in university and institutional labs for structural-activity relationship (SAR) studies and biochemical pathway investigations.
• Analytical Method Development: Critical for validating HPLC, LC-MS, and other chromatographic methods used in natural product analysis and impurity profiling.

Basic Information

Product Name	(14R)-5,6β,10,14,16-Pentahydroxygrayanotoxan-3-One
CAS No.	30272-18-5
Molecular Formula	C20H32O7
Molecular Weight	384.47 g/mol
Synonyms	Grayanotoxin III; Acetylandromedol; Andromedotoxin; Rhodojaponin III; Grayanotoxin-3; 5,6β,10,14,16-Pentahydroxygrayanotoxan-3-one; (14R)-Grayanotoxin III; Asebotoxin
EINECS	Contact for details

Quality Control

Our (14R)-5,6β,10,14,16-Pentahydroxygrayanotoxan-3-One is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for reference materials, and custom purity grades or specific impurity specifications are available upon request to meet your precise project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.