Description

24-Hydroxycholesterol is a significant oxysterol, a metabolite of cholesterol formed via the action of the enzyme cholesterol 24-hydroxylase. This compound serves as a crucial biomarker and signaling molecule in the study of cholesterol metabolism and homeostasis within the central nervous system and liver. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for biochemical research, drug discovery, and as a reference standard in analytical applications.

Application

• Biochemical Research: Used as a key intermediate and signaling molecule in studies of cholesterol metabolism, brain cholesterol turnover, and lipid raft dynamics.
• Pharmaceutical Development: Serves as a reference standard and starting material in the research and development of therapeutics targeting neurodegenerative diseases, such as Alzheimer's disease.
• Diagnostic Assays: Employed as a calibrant or control in the development of LC-MS/MS and ELISA kits for quantifying oxysterols in biological samples.
• Cell Biology Studies: Applied in vitro to investigate the effects of oxysterols on gene expression related to lipid metabolism and inflammation (e.g., via LXR receptor pathways).
• Academic Research: A vital tool for universities and research institutes exploring the role of 24-hydroxycholesterol in blood-brain barrier function and atherosclerosis.

Basic Information

Product Name	24-Hydroxycholesterol
CAS No.	30271-38-6
Molecular Formula	C27H46O2
Molecular Weight	402.66 g/mol
Synonyms	(24S)-Hydroxycholesterol; 24(S)-Hydroxycholesterol; Cerebrosterol; Cholest-5-ene-3β,24-diol; 24-HC; 24S-HC; 5-Cholestene-3β,24-diol
EINECS	Contact for details

Quality Control

Our 24-Hydroxycholesterol is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.