Description

Bufalin-3-Hydrogen Suberate is a chemically modified derivative of the potent cardiac glycoside bufalin, designed to alter its solubility and pharmacokinetic profile for advanced research applications. This compound is critical for scientists investigating the structure-activity relationships of cardiotonic steroids and their potential therapeutic pathways beyond traditional applications. It serves as a key intermediate and reference standard for pharmaceutical R&D, particularly in oncology and cardiology research, where precise molecular tools are required.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quality control and method validation in drug development.
• Biochemical Research: Employed in in vitro studies to explore the mechanisms of Na+/K+-ATPase inhibition and its downstream effects on cell signaling pathways.
• Oncology Research: Investigated for its potential anti-cancer properties, including apoptosis induction and effects on cell proliferation in various cancer cell lines.
• Metabolite & Prodrug Studies: Serves as a model compound for studying the metabolism of bufalin derivatives and the design of prodrugs with improved bioavailability.
• Chemical Synthesis Intermediate: Acts as a specialized building block for the semi-synthesis of novel bufalin analogs with tailored biological activity.

Basic Information

Product Name	Bufalin-3-Hydrogen Suberate
CAS No.	30219-13-7
Molecular Formula	C34H50O7
Molecular Weight	570.76 g/mol
Synonyms	Bufalin 3-hemisuberate; Bufalin-3-hemisuberate; 3β-[(7-Carboxyheptanoyl)oxy]-14,15-epoxy-5β,14β-bufa-20,22-dienolide; Bufalin 3-suberate; Bufalin hydrogen suberate; 14,15-Epoxy-3β-[(7-carboxyheptanoyl)oxy]-5β,14β-bufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our Bufalin-3-Hydrogen Suberate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.