Description

(20S)-17,20,21-Trihydroxypregn-4-En-3-One CAS NO 3946-10-9 is a high-purity steroid derivative, specifically a trihydroxylated pregnene compound. This chemical is a critical intermediate in the synthesis of complex steroid hormones and other biologically active molecules, valued for its defined stereochemistry at the C-20 position. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in steroid chemistry, drug discovery, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of corticosteroid drugs and other specialized steroid-based pharmaceuticals.
• Biochemical Research: Used as a reference standard or precursor in metabolic pathway studies and enzymatic reaction research involving steroid hormones.
• Steroid Chemistry Development: Serves as a starting material or intermediate for medicinal chemists exploring new steroid analogs with potential therapeutic activity.
• Reference Standard: Employed in analytical laboratories for method development, calibration, and quality control testing of related steroid compounds.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis, stereochemistry, and hormone action.

Basic Information

Product Name	(20S)-17,20,21-Trihydroxypregn-4-En-3-One
CAS No.	3946-10-9
Molecular Formula	C21H32O4
Molecular Weight	348.48 g/mol
Synonyms	17,20,21-Trihydroxypregn-4-en-3-one; (20S)-Pregn-4-ene-3,17,20,21-tetrol; 17,20,21-Trihydroxy-4-pregnen-3-one; 20S-Hydroxy Reichstein's Substance S; 20S,17,20,21-Trihydroxypregn-4-en-3-one; 4-Pregnene-17,20,21-triol-3-one
EINECS	Contact for details

Quality Control

Our (20S)-17,20,21-Trihydroxypregn-4-En-3-One is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.