Description

Triethyl 2-Phosphonopropionate is a high-purity organophosphorus compound, specifically a phosphonate ester, widely used as a critical building block in organic synthesis. Its primary value lies in its role as a versatile reagent in the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the efficient and stereoselective synthesis of α,β-unsaturated esters and other complex molecules. This product is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for constructing carbon-carbon double bonds.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing olefin linkages in active pharmaceutical ingredients (APIs) and drug candidates via the Horner-Wadsworth-Emmons reaction.
• Agrochemical Production: Used in the synthesis of advanced crop protection agents, including certain herbicides and fungicides that require specific alkene functionalities.
• Fine Chemical & Specialty Chemical Manufacturing: Serves as a versatile building block for producing flavors, fragrances, and other specialty organic compounds.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials where precise control over alkene geometry is crucial.
• Academic & Industrial R&D: A staple reagent in synthetic organic chemistry laboratories for method development and the synthesis of complex natural products and novel molecular architectures.

Basic Information

Product Name	Triethyl 2-Phosphonopropionate
CAS No.	3699-66-9
Molecular Formula	C9H19O5P
Molecular Weight	238.22 g/mol
Synonyms	Triethyl (2-ethoxycarbonylethyl)phosphonate; Diethyl (ethoxycarbonylmethyl)phosphonate; (Carbethoxymethyl)phosphonic acid diethyl ester; 2-(Diethoxyphosphoryl)propanoic acid ethyl ester; Ethyl 2-(diethoxyphosphoryl)propanoate; Triethyl phosphonopropionate; HWE Reagent for acrylates; EINECS 223-025-5
EINECS	223-025-5

Quality Control

Our Triethyl 2-Phosphonopropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the stringent requirements of advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by GC or HPLC), identity confirmation, and impurity profile is provided with every shipment to guarantee traceability and batch-to-batch reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.430 - 1.435
Density (g/mL, 20°C)	1.10 - 1.15

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.