Description

Erythronolide B is a key macrocyclic lactone intermediate in the synthesis of the erythromycin class of antibiotics. This compound is critical for ensuring the structural integrity and biological activity of the final pharmaceutical product. It is primarily required by manufacturers in the pharmaceutical and biotechnology sectors for research, development, and production of macrolide antibiotics.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the chemical synthesis of erythromycin A and its semi-synthetic derivatives (e.g., clarithromycin, azithromycin).
• API Development: Used in research and process development for new Active Pharmaceutical Ingredients (APIs) within the macrolide family.
• Biochemical Research: Employed as a reference standard or starting material in studies exploring macrolide biosynthesis, mode of action, and structure-activity relationships (SAR).
• Process Chemistry: Integral to scaling up and optimizing fermentation or synthetic routes for antibiotic production in a GMP environment.
• Quality Control: Acts as a high-purity standard for analytical methods, including HPLC and LC-MS, to ensure the purity of final antibiotic products.

Basic Information

Product Name	Erythronolide B
CAS No.	3225-82-9
Molecular Formula	C21H38O7
Molecular Weight	402.53 g/mol
Synonyms	Erythronolide B; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecane-6-carbaldehyde; 6-Deoxy-5-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-O-methyl-L-erythronolide B; Erythromycin B Aglycone; Erythronolide
EINECS	221-754-8

Quality Control

Our Erythronolide B is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.