Description

2-Fluoro-4-Chlorobenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative. This compound serves as a critical building block in advanced organic synthesis, enabling the efficient introduction of the 2-fluoro-4-chlorobenzoyl moiety. It is essential for research chemists and production facilities in the pharmaceutical and agrochemical sectors who require a reliable, high-purity intermediate for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a halogenated benzoyl group.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where its specific halogen pattern influences bioactivity.
• Liquid Crystal & OLED Material Production: Serves as a building block for advanced electronic materials and functional dyes.
• Polymer Chemistry: Employed as a monomer or modifying agent to create specialty polymers with specific thermal or chemical resistance properties.
• Peptide Coupling Reagent: Acts as an activating agent for carboxylic acids in amide bond formation reactions.
• Organic Synthesis & Research: A fundamental reagent for introducing the acyl group in Friedel-Crafts acylation and other nucleophilic substitution reactions.

Basic Information

Product Name	2-Fluoro-4-Chlorobenzoyl Chloride
CAS No.	394-39-8
Molecular Formula	C7H3Cl2FO
Molecular Weight	193.00 g/mol
Synonyms	4-Chloro-2-fluorobenzoyl chloride; 2-Fluoro-4-chlorobenzoic acid chloride; Benzoic acid, 4-chloro-2-fluoro-, chloride; 4-Chloro-2-fluorobenzoic acid chloride; 2-Fluoro-4-chlorobenzoylchloride; 4-Chloro-2-fluorobenzoylchloride; 394-39-8; 2-Fluoro-4-chloro benzoyl chloride
EINECS	206-900-9

Quality Control

Our 2-Fluoro-4-Chlorobenzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This material is hygroscopic (moisture-sensitive) and reacts violently with water, strong bases, and alcohols. Keep away from heat, sparks, and open flame. Use under an inert atmosphere (e.g., nitrogen or argon) for extended storage or after opening to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.