Description

2,2-Difluoroacetyl Chloride is a highly reactive acyl chloride derivative, serving as a critical fluorinated building block in advanced organic synthesis. Its value lies in introducing the difluoroacetyl moiety, a key structural feature that can significantly alter the metabolic stability, lipophilicity, and binding affinity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require precise fluorination to develop novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing difluoroacetate-containing drug candidates, particularly in oncology and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the difluoroacetyl group enhances biological activity and environmental profile.
• Fluorinated Polymer Production: Serves as a monomer or modifying agent for creating specialty polymers with improved chemical resistance and thermal stability.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated liquid crystals and dielectric materials for display and semiconductor applications.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation and nucleophilic acyl substitution reactions to introduce fluorinated ketone functionalities.
• Positron Emission Tomography (PET) Tracer Development: Used as a labeling precursor for incorporating fluorine-18 into radiopharmaceuticals for medical imaging.

Basic Information

Item	Details
Product Name	2,2-Difluoroacetyl Chloride
CAS No.	381-72-6
Molecular Formula	C2HF2ClO
Molecular Weight	114.48 g/mol
Synonyms	Difluoroacetyl chloride; 2,2-Difluoroethanoyl chloride; Difluoroacetic acid chloride; Chlorocarbonyl-difluoromethane; α,α-Difluoroacetyl chloride; DFAC
EINECS	206-842-6

Quality Control

Our 2,2-Difluoroacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC or titration and impurity profiling, to ensure it meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity limits is provided with every shipment to guarantee traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maintain stability and minimize hydrolysis. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) and separated from bases, oxidizers, and moisture sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.