Description

Heptafluorobutyric Acid CAS NO 375-22-4 is a highly fluorinated carboxylic acid valued for its unique combination of strong acidity and volatility. This perfluorinated compound is a critical reagent and building block in advanced chemical synthesis, particularly where its fluorine content imparts desirable properties. It is essential for manufacturers and researchers in the pharmaceutical, agrochemical, and specialty materials sectors who require high-purity fluorinated intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability.
• Derivatization Agent for Chromatography: Used as an ion-pairing agent in liquid chromatography-mass spectrometry (LC-MS) to improve the separation and detection of peptides, proteins, and basic compounds.
• Agrochemical Synthesis: Intermediate in the production of advanced fluorinated pesticides and herbicides, leveraging fluorine's ability to modulate biological activity.
• Fluorinated Surfactant & Polymer Production: Serves as a precursor for perfluorinated surfactants, coatings, and specialty polymers that demand oil, water, and stain resistance.
• Catalyst & Ligand Modification: Used to introduce perfluorinated chains into catalysts and ligands, often to facilitate product separation in fluorous-phase chemistry.
• Electronics & Semiconductor Industry: Employed in etching processes and as a precursor for chemicals used in the manufacture of electronic components.

Basic Information

Product Name	Heptafluorobutyric Acid
CAS No.	375-22-4
Molecular Formula	C4HF7O2
Molecular Weight	214.04 g/mol
Synonyms	Perfluorobutyric Acid; PFBA; 1H,1H,2H,2H-Heptafluorobutyric Acid; 2,2,3,3,4,4,4-Heptafluorobutanoic Acid; 3,3,4,4,5,5,5-Heptafluoropentanoic Acid (common misnomer); Heptafluorobuttersäure (German); Acide heptafluorobutyrique (French); NSC 9235; FC-95
EINECS	206-786-3

Quality Control

Our Heptafluorobutyric Acid is manufactured under stringent quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and purity verification by gas chromatography (GC), to ensure it meets exacting specifications for high-purity applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its nature as a strong acid and highly volatile compound, containers must be kept tightly sealed to prevent moisture absorption and evaporation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.300 - 1.305
Density (g/mL at 20°C)	1.65 - 1.68

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.