Description

Diazoxide CAS NO 364-98-7 is a potent vasodilator and antihypertensive agent belonging to the benzothiadiazine class. This compound is of significant commercial and research interest due to its primary mechanism of action as a potassium channel activator, which leads to smooth muscle relaxation. It is a critical active pharmaceutical ingredient (API) for the formulation of medications targeting severe hypertension and hypoglycemia. Key industrial users include pharmaceutical manufacturers, research institutions, and fine chemical suppliers serving the global healthcare sector.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive medications for treating malignant hypertension and hypertensive emergencies.
• Hyperinsulinism Treatment: Formulation of oral suspensions for the management of persistent hypoglycemia, particularly in pediatric cases of hyperinsulinism.
• Biochemical Research: A vital tool compound in pharmacological studies for investigating ATP-sensitive potassium (KATP) channels and vascular physiology.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical laboratories.
• Intermediate Synthesis: Used as a key synthetic intermediate in the research and development of novel therapeutic agents targeting ion channels.

Basic Information

Product Name	Diazoxide
CAS No.	364-98-7
Molecular Formula	C8H7ClN2O2S
Molecular Weight	230.67 g/mol
Synonyms	7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; SRG-95213; Hyperstat; Proglycem; Mutabase; 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide; Sch-6783
EINECS	206-668-5

Quality Control

Our Diazoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. We provide full traceability and support regulatory submissions. A detailed Certificate of Analysis (COA), including results for assay, related substances, residual solvents, and heavy metals, is available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.