Description

Hydralazine Hydrochloride is a potent, direct-acting vasodilator used primarily as an antihypertensive agent. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of cardiovascular medications. It is essential for pharmaceutical manufacturers, research institutions, and fine chemical suppliers serving the global healthcare market. Hydralazine Hydrochloride CAS NO 304-20-1 is supplied under stringent quality control to meet the demands of modern drug formulation.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the management of moderate to severe hypertension and hypertensive emergencies.
• Cardiovascular Research: A key reference standard and tool compound in preclinical studies investigating vasodilation, blood pressure regulation, and heart failure mechanisms.
• Drug Formulation Development: Used in the R&D of new dosage forms, including tablets, injectables, and combination therapies for enhanced patient compliance.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control testing, method validation, and regulatory compliance in pharmaceutical analysis.
• Biochemical Studies: Employed in studies exploring its mechanism of action on vascular smooth muscle and nitric oxide pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of finished dosage forms for global markets.

Basic Information

Product Name	Hydralazine Hydrochloride
CAS No.	304-20-1
Molecular Formula	C8H8N4·HCl
Molecular Weight	196.64 g/mol (Free base: 160.18)
Synonyms	1-Hydrazinophthalazine Hydrochloride; Hydralazine HCl; Apresoline Hydrochloride; Hydralazini Hydrochloridum; Phthalazine, 1-hydrazino-, monohydrochloride; Apresolin; Hyperazin; 1-Hydrazinylphthalazine Hydrochloride
EINECS	206-152-5

Quality Control

Our Hydralazine Hydrochloride is manufactured and tested to meet the highest pharmacopeial standards, including USP and EP monographs. Every batch undergoes rigorous analytical testing for identity, potency, purity, and specified impurities to ensure compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with each shipment to guarantee traceability and quality assurance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Microbial Enumeration	Meets USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.