Description

2-Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(2-Fluorophenyl)-3-Hydroxypropyl]-4-(4-Hydroxyphenyl)-, (3R,4S)- is a high-purity, advanced pharmaceutical intermediate with a complex stereochemistry that is critical for the synthesis of targeted therapeutic agents. This compound is valued for its role as a key chiral building block in the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring high stereochemical fidelity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small molecule drugs, where precise molecular architecture is non-negotiable.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of complex drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• API Development: Used in research and process chemistry for constructing the core β-lactam (azetidinone) scaffold in novel bioactive molecules.
• Medicinal Chemistry Research: A valuable tool compound for structure-activity relationship (SAR) studies due to its defined (3R,4S) stereochemistry and multiple functional handles (hydroxyl, fluorophenyl groups).
• Process Optimization & Scale-up: Supplied to support route scouting, process development, and cGMP manufacturing campaigns for clinical trial material.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control during API production.

Basic Information

Product Name	2-Azetidinone, 1-(4-Fluorophenyl)-3-[(3S)-3-(2-Fluorophenyl)-3-Hydroxypropyl]-4-(4-Hydroxyphenyl)-, (3R,4S)-
CAS No.	2743547-96-6
Molecular Formula	C24H21F2NO3
Molecular Weight	409.43 g/mol
Synonyms	(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(2-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3R,4S)-β-Lactam derivative with fluorophenyl and hydroxyphenyl substituents; Fluorinated azetidinone chiral intermediate; 1,3,4-Trisubstituted azetidin-2-one; Advanced β-lactam building block
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and controlled under a strict quality management system. We provide comprehensive analytical data to support your regulatory filings, including HPLC purity (typically >98.0% by area normalization), chiral purity confirmation, and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with agreed specifications. Our quality commitment aligns with the standards expected for pharmaceutical development, supporting research from discovery through to pre-clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to ensure long-term stability. Keep the container sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.