Description

1-Piperazinecarboxylic Acid, 4-[(2-Cyanophenyl)Methyl]-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a strategically positioned cyano-benzyl substituent. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the multi-step synthesis of novel drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop compounds with improved potency and selectivity.
• API Development: A crucial precursor in the scalable production of active pharmaceutical ingredients (APIs) for preclinical and clinical trials.
• CNS Drug Discovery: Its structural features make it valuable for constructing molecules intended to cross the blood-brain barrier for neurological and psychiatric applications.
• Oncology Therapeutics: Employed in the synthesis of potential kinase inhibitors and other targeted cancer therapies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Item	Details
Product Name	1-Piperazinecarboxylic Acid, 4-[(2-Cyanophenyl)Methyl]-, 1,1-Dimethylethyl Ester
CAS No.	2703756-90-3
Molecular Formula	C17H23N3O2
Molecular Weight	301.39 g/mol
Synonyms	tert-Butyl 4-(2-cyanobenzyl)piperazine-1-carboxylate; 4-(2-Cyanobenzyl)piperazine-1-carboxylic acid tert-butyl ester; Boc-4-(2-cyanobenzyl)piperazine; N-Boc-4-(2-cyanobenzyl)piperazine; 1-(tert-Butoxycarbonyl)-4-[(2-cyanophenyl)methyl]piperazine; 1-N-Boc-4-(2-cyanobenzyl)piperazine; 4-(2-Cyanobenzyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 4-[(2-Cyanophenyl)Methyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.