Description

1-Piperidineacetic Acid, 4-[4-[(2,6-Dioxo-3-Piperidinyl)Amino]Phenyl]-, 1,1-Dimethylethyl Ester is a high-purity, complex organic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of targeted protein degraders, such as Proteolysis Targeting Chimeras (PROTACs), and other novel therapeutic modalities. It is essential for medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries seeking to develop next-generation treatments.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and other bifunctional molecules designed for targeted protein degradation.
• Medicinal Chemistry Research: Used in the discovery and optimization of novel drug candidates, particularly in oncology and neurodegenerative disease research.
• Chemical Biology Probes: Employed in the development of tool compounds for studying cellular pathways and protein function.
• Linker Component: Serves as a sophisticated chemical linker connecting E3 ligase ligands with target protein binders in heterobifunctional molecule design.
• Process Development: Used in scaling up synthetic routes for advanced therapeutic candidates under cGMP conditions.
• Academic Research: A valuable reagent for universities and research institutes exploring novel mechanisms of drug action.

Basic Information

Product Name	1-Piperidineacetic Acid, 4-[4-[(2,6-Dioxo-3-Piperidinyl)Amino]Phenyl]-, 1,1-Dimethylethyl Ester
CAS No.	2641512-32-3
Molecular Formula	C22H31N3O5
Molecular Weight	417.50 g/mol
Synonyms	tert-Butyl 4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidine-1-acetate; 4-[4-[(2,6-Dioxo-3-piperidinyl)amino]phenyl]-1-piperidineacetic Acid 1,1-Dimethylethyl Ester; PROTAC Linker; E3 Ligase Ligand-Linker Conjugate; Cereblon Ligand-Linker Conjugate 1; (2,6-Dioxo-3-piperidinyl)-[4-(1-tert-butoxycarbonylmethyl-piperidin-4-yl)-phenyl]-amine; tert-Butyl 2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)acetate
EINECS	Contact for details

Quality Control

Our 1-Piperidineacetic Acid, 4-[4-[(2,6-Dioxo-3-Piperidinyl)Amino]Phenyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All batches are supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry best practices and can support development projects requiring material produced under cGMP guidelines for non-clinical and clinical stage use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.