Description

4-Nitrobenzyl 2-(((tert-Butyldimethylsilyl)Oxy)Methyl)-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate is a sophisticated, multi-functional organic intermediate featuring both a nitrobenzyl ester and a tert-butyldimethylsilyl (TBDMS) protected hydroxyl group. This compound matters for its critical role as a key building block in modern pharmaceutical synthesis, particularly for the development of complex heterocyclic active pharmaceutical ingredients (APIs). Pharmaceutical R&D teams and fine chemical manufacturers need this high-purity intermediate to enable efficient, multi-step synthetic routes where selective deprotection and further functionalization are required.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, especially within the pyrazolo[1,5-a]pyrazine scaffold class.
• Protease Inhibitor Research: Used in the development of inhibitors targeting specific enzymes, leveraging its unique heterocyclic structure.
• Kinase Inhibitor Synthesis: Acts as a building block for potential kinase inhibitors, a major therapeutic area in oncology and inflammatory diseases.
• Peptidomimetic Chemistry: Employed in the design and synthesis of peptidomimetics, where the TBDMS group allows for orthogonal protection strategies.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Process Chemistry Development: Applied in route scouting and optimization for the scalable production of advanced pharmaceutical intermediates.
• Academic & Contract Research: Supports medicinal chemistry programs in academic institutions and contract research organizations (CROs).

Basic Information

Product Name	4-Nitrobenzyl 2-(((tert-Butyldimethylsilyl)Oxy)Methyl)-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate
CAS No.	2460029-00-7
Molecular Formula	C22H30N4O5Si
Molecular Weight	458.59 g/mol
Synonyms	5(4H)-Pyrazolo[1,5-a]pyrazine-5-carboxylic acid, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6,7-dihydro-, 4-nitrobenzyl ester; 4-Nitrobenzyl 2-(((TBDMS)Oxy)Methyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate; TBDMS-protected pyrazolopyrazine nitrobenzyl ester; 2460029-00-7; 4-Nitrobenzyl 2-((tert-butyldimethylsilyloxy)methyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-5-carboxylate
EINECS	Contact for details

Quality Control

Our 4-Nitrobenzyl 2-(((tert-Butyldimethylsilyl)Oxy)Methyl)-6,7-Dihydropyrazolo[1,5-A]Pyrazine-5(4H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available upon request. We support development and commercial projects requiring material that meets stringent internal specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.