Description

(S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-6-One Hydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. This compound is critical for research and development in medicinal chemistry, particularly for the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic research institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent and selective drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities with improved efficacy and safety profiles.
• API Development: Serves as a critical precursor in the development and scale-up of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Asymmetric Synthesis: Utilized as a scaffold or reagent in asymmetric catalytic processes to introduce stereochemical complexity.
• Biochemical Research: May be employed as a tool compound or ligand in biochemical assays to study specific enzyme or receptor interactions.

Basic Information

Product Name	(S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-6-One Hydrochloride
CAS No.	2445347-90-8
Molecular Formula	C8H15ClN2O
Molecular Weight	190.67 g/mol
Synonyms	(S)-Octahydro-1H-pyrrolo[1,2-a]pyrazin-1-one hydrochloride; (S)-1,2,3,4,6,7,8,8a-Octahydropyrrolo[1,2-a]pyrazin-1-one hydrochloride; (S)-Hexahydropyrrolo[1,2-a]pyrazin-6(1H)-one hydrochloride; (S)-Pyrrolo[1,2-a]pyrazin-6-one, hexahydro-, hydrochloride, (8aS)-; (8aS)-Octahydro-1H-pyrrolo[1,2-a]pyrazin-1-one hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-6-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.