Description

3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaheptatriacontane-1-Thiol is a high-purity, long-chain polyethylene glycol (PEG) derivative functionalized with a terminal thiol (-SH) group. This unique structure makes it a critical building block for creating stable, biocompatible conjugates and surfaces through thiol-based click chemistry, such as Michael addition or thiol-ene reactions. It is essential for researchers and manufacturers in advanced material science, bioconjugation, and nanotechnology who require precise surface modification and linker functionality.

Application

• Bioconjugation and Protein Modification: Used as a heterobifunctional crosslinker for attaching peptides, proteins, or drugs to nanoparticles, surfaces, or other biomolecules via the reactive thiol group.
• Surface Functionalization and Self-Assembled Monolayers (SAMs): The thiol terminus allows for covalent attachment to gold, silver, and other metal surfaces, creating PEGylated, non-fouling, or bio-reactive coatings for sensors and medical devices.
• Nanoparticle Stabilization and Capping: Acts as a stabilizing agent for metallic nanoparticles (e.g., gold nanorods, quantum dots), providing colloidal stability and a platform for further functionalization.
• Hydrogel and Polymer Network Formation: Serves as a crosslinking agent in the synthesis of PEG-based hydrogels, contributing to tunable mechanical properties and biocompatibility for tissue engineering and drug delivery systems.
• Lipid Nanoparticle (LNP) and Micelle Functionalization: Incorporated into lipid or polymeric assemblies to introduce stealth properties (PEGylation) and reactive sites for targeted drug delivery applications.
• Diagnostic Assay Development: Utilized to immobilize capture antibodies or probes on sensor chips and microplates, enhancing assay sensitivity and reducing non-specific binding.

Basic Information

Product Name	3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaheptatriacontane-1-Thiol
CAS No.	2413368-61-1
Molecular Formula	C25H52O12S
Molecular Weight	576.75 g/mol
Synonyms	HS-PEG12-OH; α-Thiol-ω-hydroxy-dodecaethylene glycol; 1-Mercapto-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaheptatriacontan-37-ol; Thiol-PEG12-alcohol; PEG12 dithiol (asymmetric); mPEG-Thiol, 12-mer; O-(2-Mercaptoethyl)-O'-methyl-dodecaethylene glycol; Heterobifunctional PEG, SH-PEG-OH (MW ~576)
EINECS	Contact for details

Quality Control

Every batch of 3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxaheptatriacontane-1-Thiol is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR, HPLC, and titration to verify identity, purity, and functional group integrity. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and moisture content is provided with each shipment to ensure it meets your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C. For long-term stability, desiccants are recommended. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Thiol Content (Titration)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.