Description

m-Peg10-Acid CAS NO 2409969-94-2 is a monodisperse polyethylene glycol (PEG) derivative featuring a carboxylic acid functional group at one terminus and a methoxy group at the other. This bifunctional linker is critical for creating stable, water-soluble conjugates in advanced pharmaceutical and biotech applications. It is primarily used by researchers and manufacturers in drug delivery, bioconjugation, and materials science who require precise, reproducible, and high-purity PEGylation reagents.

Application

• Pharmaceutical PEGylation: Conjugation to peptides, proteins, and oligonucleotides to enhance solubility, stability, and circulation half-life.
• Bioconjugation & Linker Chemistry: Acts as a heterobifunctional crosslinker for attaching drugs, dyes, or targeting ligands to antibodies, nanoparticles, or other biomolecules.
• Drug Delivery Systems: Functionalization of liposomes, dendrimers, and polymeric micelles to create stealth carriers and targeted therapeutics.
• Surface Modification: Crafting hydrophilic, non-fouling coatings on medical devices, biosensors, and diagnostic platforms.
• Hydrogel Formation: Serving as a water-soluble macromer for creating biocompatible and tunable hydrogel networks.
• ADC (Antibody-Drug Conjugate) Development: Providing a stable, cleavable, or non-cleavable spacer between the antibody and the cytotoxic payload.

Basic Information

Product Name	m-Peg10-Acid
CAS No.	2409969-94-2
Molecular Formula	C23H46O12
Molecular Weight	514.61 g/mol
Synonyms	mPEG10-acid; Methoxy-PEG10-acid; α-Methoxy-ω-carboxy-poly(ethylene glycol); 2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-oic acid, 31-methoxy-; mPEG10-COOH; O-(2-Carboxyethyl)-O'-methyl-nonaethylene glycol; Monomethoxy PEG10 carboxylic acid; PEG spacer 10 acid
EINECS	Contact for details

Quality Control

Every batch of m-Peg10-Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive bioconjugation work. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for purity (HPLC), identity (NMR, IR), and critical parameters like acid value and polydispersity. Our quality commitment supports applications in GMP and cGMP environments where traceability and consistency are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent moisture absorption and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Acid Value	Theoretical ± 5%
Water Content (KF)	≤ 1.0%
Molecular Weight (NMR)	500 - 530 g/mol
Polydispersity Index (PDI)	≤ 1.05

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.