Description

((2S,5S)-5-Methylpiperazin-2-yl)methanol dihydrochloride is a high-purity, stereochemically defined chiral piperazine derivative supplied as a stable dihydrochloride salt. This compound serves as a critical pharmaceutical intermediate and chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• API Synthesis: Used as a building block for constructing the core piperazine scaffold found in various proprietary pharmaceutical compounds.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce chiral complexity into target molecules.
• Chemical Reference Standard: Acts as a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	((2S,5S)-5-Methylpiperazin-2-yl)methanol Dihydrochloride
CAS No.	2407907-33-7
Molecular Formula	C6H16Cl2N2O
Molecular Weight	203.11 g/mol
Synonyms	(2S,5S)-5-Methyl-2-piperazinemethanol dihydrochloride; (5-Methylpiperazin-2-yl)methanol dihydrochloride ((2S,5S)-isomer); 2-Piperazinemethanol, 5-methyl-, dihydrochloride, (2S,5S)-; (2S,5S)-5-Methylpiperazine-2-carbinol dihydrochloride; (2S,5S)-HMP dihydrochloride; (2S,5S)-5-Methyl-2-(hydroxymethyl)piperazine dihydrochloride
EINECS	Contact for details

Quality Control

Our ((2S,5S)-5-Methylpiperazin-2-yl)methanol dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.