Description

1,6-Naphthyridine-3-Carboxamide, 4-(4-Cyano-2-Methoxyphenyl)-1,4-Dihydro-2,8-Dimethyl-5-(3-Oxetanylmethoxy)-, (4R)- is a high-purity, chiral pharmaceutical intermediate of significant interest in modern drug discovery. This compound is valued for its complex molecular architecture, which serves as a key building block in the synthesis of targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel small-molecule drugs, particularly in oncology and other disease areas requiring precise molecular targeting.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• API Development: Employed as a precursor in the development and scale-up of active pharmaceutical ingredients (APIs) with specific stereochemical requirements.
• Biochemical Research: Utilized as a tool compound or ligand in biochemical assays to study enzyme inhibition or receptor binding mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Used in university and institutional labs for advanced organic synthesis methodology development and chemical biology studies.

Basic Information

Product Name	1,6-Naphthyridine-3-Carboxamide, 4-(4-Cyano-2-Methoxyphenyl)-1,4-Dihydro-2,8-Dimethyl-5-(3-Oxetanylmethoxy)-, (4R)-
CAS No.	2389019-51-4
Molecular Formula	C24H24N4O4
Molecular Weight	432.47 g/mol
Synonyms	(4R)-4-(4-Cyano-2-methoxyphenyl)-1,4-dihydro-2,8-dimethyl-5-(3-oxetanylmethoxy)-1,6-naphthyridine-3-carboxamide; (4R)-4-(4-Cyano-2-methoxyphenyl)-5-((oxetan-3-yl)methoxy)-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide; UNII-7V5Q8S35Q4; 7V5Q8S35Q4; 2389019-51-4; (R)-4-(4-Cyano-2-methoxyphenyl)-5-((oxetan-3-yl)methoxy)-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide; AChE Inhibitor Intermediate; Oxetanyl Naphthyridine Carboxamide Derivative
EINECS	Contact for details

Quality Control

Our 1,6-Naphthyridine-3-Carboxamide derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and development grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request to support regulatory filings and internal quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The container should be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.