Description

Tolpentamide CAS NO 1027-87-8 is a high-purity sulfonylurea derivative, a key intermediate in the synthesis of advanced pharmaceutical compounds. Its precise chemical structure and consistent quality are critical for ensuring the efficacy and safety of downstream active pharmaceutical ingredients (APIs). This product is essential for research institutions and manufacturers in the pharmaceutical industry engaged in the development and production of therapeutic agents.

Application

• Pharmaceutical Intermediate: Primary use as a crucial building block in the synthesis of sulfonylurea-based drug candidates.
• Metabolic Research: Used in biochemical and pharmacological research related to metabolic pathways and enzyme inhibition studies.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical laboratories.
• API Synthesis: A key precursor in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) targeting specific receptors.

Basic Information

Product Name	Tolpentamide
CAS No.	1027-87-8
Molecular Formula	C12H18N2O3S
Molecular Weight	270.35 g/mol
Synonyms	1-Butyl-3-(p-tolylsulfonyl)urea; Tolazamide Impurity A; N-Butyl-N'-(4-methylphenyl)sulfonylurea; Tolbutamide analog; BTS 67 083; 4-Methyl-N-[(butylamino)carbonyl]benzenesulfonamide
EINECS	213-842-4

Quality Control

Our Tolpentamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substances, to meet the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which could affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.