Description

2-Pyrazinecarboxamide, n-[(1S)-2-[(3-Hydroxy-3-Methyl-1-Oxobutyl)Amino]-2-Oxo-1-(Phenylmethyl)Ethyl]- is a high-purity, chiral synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring a pyrazinecarboxamide core and a phenylmethyl group, makes it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing targeted therapies, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Protease Inhibitor Research: Used in the development and study of novel protease inhibitors due to its peptide-like amide bond structure.
• Chemical Biology Probe Synthesis: Employed in constructing molecular probes for studying enzyme function and protein-protein interactions in biological systems.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in asymmetric catalytic reactions to introduce specific stereochemistry into complex molecules.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in medicinal chemistry and organic synthesis methodologies.
• Custom Synthesis & Contract Manufacturing: Provided to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Item	Details
Product Name	2-Pyrazinecarboxamide, n-[(1S)-2-[(3-Hydroxy-3-Methyl-1-Oxobutyl)Amino]-2-Oxo-1-(Phenylmethyl)Ethyl]-
CAS No.	2379402-85-2
Molecular Formula	C19H22N4O4
Molecular Weight	370.41 g/mol
Synonyms	N-[(2S)-2-Benzyl-2-[(3-hydroxy-3-methylbutanoyl)amino]acetyl]pyrazine-2-carboxamide; (2S)-2-Benzyl-2-[(3-hydroxy-3-methylbutanoyl)amino]-N-(pyrazin-2-yl)acetamide; L-Phenylalanine, N-(3-hydroxy-3-methyl-1-oxobutyl)-, 2-pyrazinylamide; A bespoke chiral pyrazine derivative intermediate. Contact for additional aliases.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ state-of-the-art analytical techniques, including HPLC, GC, and NMR, to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment. Our quality commitment aligns with cGMP principles where applicable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.