Description

Ho-Peg10-Ch2Ch2Cooh CAS NO 2375611-66-6 is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a hydroxyl group and a carboxylic acid terminus, separated by a precisely defined PEG10 spacer. This molecular architecture is critical for creating stable, water-soluble conjugates and linkers in advanced bioconjugation and materials science applications. It is an essential building block for researchers and manufacturers in the pharmaceutical, diagnostic, and nanotechnology sectors who require reliable, high-purity intermediates for developing novel therapeutics and functional materials.

Application

• Bioconjugation Linker: For coupling peptides, proteins, or antibodies to surfaces, nanoparticles, or other biomolecules via its orthogonal hydroxyl and carboxyl functional groups.
• PEGylation Reagent: Used in the synthesis of PEGylated drug conjugates to improve pharmacokinetics, solubility, and stability of active pharmaceutical ingredients (APIs).
• Polymer Chemistry Intermediate: Serves as a macromonomer or cross-linking agent in the synthesis of functionalized hydrogels, smart materials, and biocompatible coatings.
• Diagnostic Probe Synthesis: Facilitates the attachment of targeting ligands (e.g., antibodies, peptides) to fluorescent dyes or contrast agents for imaging applications.
• Surface Functionalization: Used to modify the surface properties of nanoparticles, quantum dots, or medical devices to enhance biocompatibility and introduce specific chemical handles.
• Drug Delivery System Component: Incorporated into the design of micelles, liposomes, and dendrimers for targeted and controlled drug release.

Basic Information

Product Name	Ho-Peg10-Ch2Ch2Cooh
CAS No.	2375611-66-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	HO-PEG10-COOH; Hydroxy-PEG10-acetic acid; α-Hydroxy-ω-carboxy PEG10; 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; 15-Hydroxy-4,7,10,13-tetraoxapentadecan-1-oic acid (PEG10 analog); Heterobifunctional PEG10; HO-(CH2CH2O)10-CH2COOH; Carboxy-PEG10-alcohol
EINECS	Contact for details

Quality Control

Our Ho-Peg10-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and commercial applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Distribution (GPC)	Contact for details
Functional Group Assay	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.