Description

tert-Butyl (2S,5S)-5-(Hydroxymethyl)-2-Methylpiperazine-1-Carboxylate is a high-purity, chiral piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for its utility in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• API Development: Used as a sophisticated building block in the research and scale-up of complex, stereochemically defined active pharmaceutical ingredients.
• Agrochemical Synthesis: Intermediate in the production of advanced, enantiomerically pure agrochemicals requiring specific stereochemistry for optimal activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Valuable scaffold in medicinal chemistry for the design and synthesis of peptidomimetic compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	tert-Butyl (2S,5S)-5-(Hydroxymethyl)-2-Methylpiperazine-1-Carboxylate
CAS No.	2375424-00-1
Molecular Formula	C12H24N2O3
Molecular Weight	244.33 g/mol
Synonyms	1-Boc-(2S,5S)-5-(Hydroxymethyl)-2-methylpiperazine; (2S,5S)-1-(tert-Butoxycarbonyl)-5-(hydroxymethyl)-2-methylpiperazine; tert-Butyl (2S,5S)-5-(hydroxymethyl)-2-methyl-1-piperazinecarboxylate; Boc-(2S,5S)-5-Hydroxymethyl-2-methylpiperazine; (2S,5S)-2-Methyl-5-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester; (S,S)-1-Boc-5-Hydroxymethyl-2-methylpiperazine; Chiral Boc-protected hydroxymethyl piperazine derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl (2S,5S)-5-(Hydroxymethyl)-2-Methylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.