Description

1-Piperazinecarboxylic Acid, 5-(Hydroxymethyl)-2-Methyl-, 1,1-Dimethylethyl Ester, (2R,5S)- is a high-purity, stereochemically defined piperazine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected, functionalized scaffold that enables the precise construction of complex molecular architectures with defined stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) and other fine chemicals where structural precision is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Agrochemical Development: Used in constructing advanced, stereoselective active ingredients for crop protection products.
• Peptidomimetics & Bioactive Molecule Synthesis: The piperazine core and functional groups make it valuable for creating peptide analogs and other biologically active compounds.
• Ligand & Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Academic & Industrial R&D: A versatile building block for medicinal chemistry programs and process chemistry development in laboratory and pilot-scale settings.
• Custom Synthesis Projects: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule assembly.

Basic Information

Item	Details
Product Name	1-Piperazinecarboxylic Acid, 5-(Hydroxymethyl)-2-Methyl-, 1,1-Dimethylethyl Ester, (2R,5S)-
CAS No.	2375423-99-5
Molecular Formula	C12H23N2O3
Molecular Weight	243.32 g/mol
Synonyms	(2R,5S)-tert-Butyl 5-(hydroxymethyl)-2-methylpiperazine-1-carboxylate; (2R,5S)-Boc-5-(hydroxymethyl)-2-methylpiperazine; (2R,5S)-N-Boc-5-(hydroxymethyl)-2-methylpiperazine; (2R,5S)-1-(tert-Butoxycarbonyl)-5-(hydroxymethyl)-2-methylpiperazine; (2R,5S)-1-Boc-5-(hydroxymethyl)-2-methylpiperazine; (2R,5S)-tert-Butyl 5-(hydroxymethyl)-2-methyl-1-piperazinecarboxylate; (2R,5S)-5-(Hydroxymethyl)-2-methylpiperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxylic Acid, 5-(Hydroxymethyl)-2-Methyl-, 1,1-Dimethylethyl Ester, (2R,5S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (2R,5S)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.