Description

(5-Aminopyrazin-2-Yl)Dimethylphosphine Oxide CAS NO 2361977-52-6 is a high-purity, functionalized heterocyclic phosphine oxide building block of significant interest in advanced organic synthesis. Its unique structure, featuring both an amino group and a phosphine oxide moiety on a pyrazine core, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as ligand synthesis, catalyst development, and the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold for bioactivity.
• Ligand Synthesis: The aminopyrazine and phosphine oxide functionalities make it a precursor for designing specialized ligands in transition metal catalysis.
• Material Science Precursor: Employed in the research and development of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a starting material for creating molecular probes to study biological pathways and enzyme functions.
• Cross-Coupling Reactions: Can be utilized as a functionalized substrate in palladium-catalyzed cross-coupling reactions to create complex biaryl systems.

Basic Information

Item	Details
Product Name	(5-Aminopyrazin-2-Yl)Dimethylphosphine Oxide
CAS No.	2361977-52-6
Molecular Formula	C7H12N3OP
Molecular Weight	185.16 g/mol
Synonyms	Dimethyl(5-aminopyrazin-2-yl)phosphine oxide; 5-Amino-2-(dimethylphosphinyl)pyrazine; (5-Amino-2-pyrazinyl)dimethylphosphine oxide; 2-Pyrazinamine, 5-(dimethylphosphinyl)-; 2361977-52-6; Aminopyrazinyl dimethylphosphine oxide
EINECS	Contact for details

Quality Control

Every batch of (5-Aminopyrazin-2-Yl)Dimethylphosphine Oxide is produced and tested under strict quality management protocols to ensure consistency and reliability for research and development purposes. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.