Description

1-Piperazinebutanoic Acid, 4-[(1,1-Dimethylethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, multi-functional scaffold for constructing complex molecules with precise stereochemistry and functional group compatibility. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine moieties into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand Synthesis for Catalysis: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Employed in the synthesis of new generation herbicides and fungicides that require specific heterocyclic architectures.
• Custom Chemical Synthesis: Provides a protected, bifunctional handle for contract research organizations (CROs) and CDMOs building bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and combinatorial chemistry.

Basic Information

Product Name	1-Piperazinebutanoic Acid, 4-[(1,1-Dimethylethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester
CAS No.	2361021-88-5
Molecular Formula	C18H34N2O4
Molecular Weight	342.48 g/mol
Synonyms	tert-Butyl 4-(3-(tert-butoxy)-3-oxopropyl)piperazine-1-carboxylate; 1-Boc-4-(3-tert-butoxy-3-oxopropyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(3-tert-butoxy-3-oxopropyl)piperazine; 4-(3-(tert-Butoxy)-3-oxopropyl)piperazine-1-carboxylic acid tert-butyl ester; Boc-Pip(3-COOtBu)-OH (protected form); N-Boc-4-(3-tert-butoxycarbonylpropyl)piperazine; Piperazine-1-carboxylic acid, 4-[3-[(1,1-dimethylethoxy)carbonyl]propyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Piperazinebutanoic Acid, 4-[(1,1-Dimethylethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are provided to guarantee the material meets your specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.