Description

tert-Butyl (3S,4R)-4-Amino-3-Methoxypiperidine-1-Carboxylate Hydrochloride is a high-purity, stereochemically defined chiral piperidine derivative, serving as a critical building block in modern organic synthesis. Its value lies in providing a protected, functionalized scaffold essential for constructing complex molecules with precise three-dimensional control. This advanced pharmaceutical intermediate is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor to introduce stereogenic centers in complex organic molecules.
• Process Chemistry Development: Serves as a starting material for scaling up the production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	tert-Butyl (3S,4R)-4-Amino-3-Methoxypiperidine-1-Carboxylate Hydrochloride
CAS No.	2355288-63-8
Molecular Formula	C12H25ClN2O3
Molecular Weight	280.79 g/mol
Synonyms	1-Boc-4-Amino-3-methoxypiperidine Hydrochloride; (3S,4R)-1-(tert-Butoxycarbonyl)-4-amino-3-methoxypiperidine Hydrochloride; tert-Butyl (3S,4R)-4-amino-3-methoxy-1-piperidinecarboxylate Hydrochloride; (3S,4R)-4-Amino-3-methoxy-N-Boc-piperidine HCl; 1-N-Boc-4-amino-3-methoxypiperidine hydrochloride; 4-Amino-3-methoxy-1-piperidinecarboxylic acid tert-butyl ester hydrochloride; (3S,4R)-1-Boc-4-amino-3-methoxypiperidine HCl
EINECS	Contact for details

Quality Control

Our tert-Butyl (3S,4R)-4-Amino-3-Methoxypiperidine-1-Carboxylate Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. We provide comprehensive analytical data, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each batch to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.