Description

Tco-Peg8-Acid CAS NO 2353410-03-2 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a tert-butyloxycarbonyl (Tco) protecting group and a terminal carboxylic acid. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise, controlled linkage of bioactive molecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for creating stable, functionalized conjugates.

Application

• Bioconjugation Reagent: Used for the site-specific modification of peptides, proteins, and antibodies to enhance solubility, stability, or pharmacokinetic properties.
• Pharmaceutical Linker: Serves as a key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• PEGylation Chemistry: Acts as a functional PEG spacer to introduce carboxylic acid groups for further coupling reactions in drug delivery system development.
• Proteomics Research: Employed in the labeling and cross-linking of biomolecules for analytical and diagnostic applications.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and other material surfaces with bioactive ligands.
• Polymer Synthesis: A versatile monomer for creating functionalized, biodegradable, or stimuli-responsive polymeric materials.

Basic Information

Product Name	Tco-Peg8-Acid
CAS No.	2353410-03-2
Molecular Formula	C31H59NO13
Molecular Weight	653.8 g/mol
Synonyms	1-(1,3-Dioxoisoindolin-2-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid; 2,5-Dioxopyrrolidin-1-yl 3,6,9,12,15,18,21,24-octaoxaheptacos-26-yl carbonate; TCO-PEG8-COOH; tert-Butyloxycarbonyl-PEG8-acid; Boc-PEG8-acid; TCO-PEG8-Acid; N-(tert-Butoxycarbonyl)-PEG8-acid
EINECS	Contact for details

Quality Control

Our Tco-Peg8-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.