Description

m-Peg8-Ethoxycarbonyl-Propanoic Acid is a high-purity, functionalized polyethylene glycol (PEG) derivative designed for advanced bioconjugation and pharmaceutical applications. This compound is valued for its heterobifunctional nature, featuring a carboxylic acid group and a protected active ester, enabling precise and controlled linkage to biomolecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and advanced material science to create stable, water-soluble conjugates for drug delivery systems and diagnostic reagents.

Application

• Bioconjugation Reagent: For the site-specific modification of peptides, proteins, and antibodies to enhance solubility, stability, and pharmacokinetic properties.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• PEGylation Linker: Used to attach polyethylene glycol chains to drug molecules, a process known as PEGylation, to reduce immunogenicity and prolong circulation half-life.
• Diagnostic Probe Synthesis: Enables the labeling of biomolecules with fluorescent dyes or other reporter groups for in vitro and in vivo diagnostics.
• Polymer Chemistry: Acts as a functional monomer or cross-linker for creating hydrogels and smart polymers with tailored degradation profiles.
• Surface Functionalization: Used to modify nanoparticles and other material surfaces to improve biocompatibility and enable specific targeting.

Basic Information

Product Name	m-Peg8-Ethoxycarbonyl-Propanoic Acid
CAS No.	2353409-75-1
Molecular Formula	C24H46O13
Molecular Weight	542.62 g/mol
Synonyms	8-((2,5-Dioxopyrrolidin-1-yl)oxy)-8-oxo-3,6,9,12,15,18,21,24-octaoxaoctacosan-28-oic acid; mPEG8-NHS ester acid; α-Methoxy-ω-carboxy-PEG8-NHS ester; NHS-PEG8-COOH; 1-(Methoxy(polyethyleneoxy)propyl) 2,5-dioxopyrrolidine-1-carboxylate propanoic acid; Carboxy-PEG8-NHS ester; Succinimidyl ester of mPEG8-acid
EINECS	Contact for details

Quality Control

Our m-Peg8-Ethoxycarbonyl-Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability, consistency, and compliance with research and cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms
Functional Group Assay (NHS Ester)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.