Description

1-tert-Butyl 3-Methyl (3R,6R)-6-Methylpiperazine-1,3-Dicarboxylate is a high-purity, stereochemically defined chiral piperazine derivative used as a critical building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise molecular architecture for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. Its primary value lies in its role as a key chiral intermediate, enabling the synthesis of complex molecules with high enantiomeric purity for the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Incorporated into the backbone of peptidomimetic compounds to modulate biological activity and stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high stereochemical fidelity.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry and process chemistry research in both academic and industrial laboratories.

Basic Information

Product Name	1-tert-Butyl 3-Methyl (3R,6R)-6-Methylpiperazine-1,3-Dicarboxylate
CAS No.	2349395-78-2
Molecular Formula	C12H22N2O4
Molecular Weight	258.31 g/mol
Synonyms	(3R,6R)-1-(tert-Butoxycarbonyl)-6-methylpiperazine-3-carboxylic acid methyl ester; Methyl (3R,6R)-1-Boc-6-methylpiperazine-3-carboxylate; (3R,6R)-1-Boc-6-methylpiperazine-3-carboxylic acid methyl ester; (3R,6R)-6-Methyl-1-Boc-piperazine-3-carboxylic acid methyl ester; tert-Butyl (3R,6R)-3-(methoxycarbonyl)-6-methylpiperazine-1-carboxylate; (3R,6R)-1-N-Boc-6-methylpiperazine-3-methyl carboxylate; BOC-(3R,6R)-6-Methylpiperazine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 1-tert-Butyl 3-Methyl (3R,6R)-6-Methylpiperazine-1,3-Dicarboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure compliance with exacting purity and stereochemical specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess, and impurity profiles is provided with each shipment to guarantee reliable and consistent performance in your critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.