Description

2-Piperazinemethanol, 5-Methyl-, (2R,5R)- Dihydrochloride is a high-purity, stereochemically defined chiral piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized scaffold essential for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, process development, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce specific stereochemistry and functional groups.
• Process Chemistry: Serves as a starting material or intermediate in the scalable synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Agrochemical Research: Employed in the development of new chiral pesticides and herbicides where specific stereochemistry impacts biological activity.
• Catalyst Ligand Synthesis: Potential precursor for the synthesis of chiral ligands used in asymmetric catalysis.
• Academic & Contract Research: Utilized in universities and CROs for fundamental research in organic synthesis and methodology development.

Basic Information

Product Name	2-Piperazinemethanol, 5-Methyl-, (2R,5R)- Dihydrochloride
CAS No.	2349395-67-9
Molecular Formula	C6H14N2O • 2HCl
Molecular Weight	215.11 g/mol
Synonyms	(2R,5R)-5-Methyl-2-piperazinemethanol dihydrochloride; (2R,5R)-5-Methylpiperazine-2-methanol dihydrochloride; (2R,5R)-5-Methyl-2-piperazinmethanol dihydrochloride; (2R,5R)-5-Methyl-2-(hydroxymethyl)piperazine dihydrochloride; (2R,5R)-2-(Hydroxymethyl)-5-methylpiperazine dihydrochloride; (2R,5R)-5-Methyl-2-piperazinylmethanol dihydrochloride; CAS 2349395-67-9
EINECS	Contact for details

Quality Control

Our 2-Piperazinemethanol, 5-Methyl-, (2R,5R)- Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.